An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C [double bond, length as m-dash] O and C [double bond …
X del Corte, EM de Marigorta, F Palacios… - Organic Chemistry …, 2022 - pubs.rsc.org
Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …
examples were reported 18 years ago by Akiyama and Terada. Although they were …
Recent Advances in the Direct Functionalization of Isoindolinones for the Synthesis of 3, 3‐Disubstituted Isoindolinones
L Chen, YX Zou - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
The construction of tetrasubstituted carbon centers (especially chiral ones) represents one of
the most challenging and demanding topics in the synthesis of natural products and related …
the most challenging and demanding topics in the synthesis of natural products and related …
Catalytic enantioselective synthesis of difluoromethylated tetrasubstituted stereocenters in isoindolones enabled by a multiple-fluorine system
MY Rong, JS Li, Y Zhou, FG Zhang, JA Ma - Organic Letters, 2020 - ACS Publications
A poly trifluoromethylated chiral spirocyclic phosphoric acid was developed and employed
with hexafluoroisoproyl alcohol (HFIP) to render the catalytic asymmetric Mukaiyama …
with hexafluoroisoproyl alcohol (HFIP) to render the catalytic asymmetric Mukaiyama …
Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction
An efficient enantioselective formal Betti reaction between phenols and diaryl ketimines
generated in situ from isoindolinone alcohols is described. In a reaction catalyzed by a chiral …
generated in situ from isoindolinone alcohols is described. In a reaction catalyzed by a chiral …
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones
N Topolovčan, M Gredičak - Organic & biomolecular chemistry, 2021 - pubs.rsc.org
This review focuses on the synthesis of 3-hydroxyisoindolinones, and their application as
substrates in stereoselective catalytic transformations reported from 2010 to date. These …
substrates in stereoselective catalytic transformations reported from 2010 to date. These …
Asymmetric catalytic ketimine Mannich reactions and related transformations
The catalytic enantioselective ketimine Mannich and its related reactions provide direct
access to chiral building blocks bearing an α-tertiary amine stereogenic center, a ubiquitous …
access to chiral building blocks bearing an α-tertiary amine stereogenic center, a ubiquitous …
Enantioselective construction of chiral gem-difluorinated C2-quaternary indoline via dual MgSO 4–CPA-catalyzed asymmetric Mannich reactions
XC Wang, XP Wei, CP Zou, T Ma, Y He, G Li… - Organic Chemistry …, 2024 - pubs.rsc.org
The construction of the–CF2 moiety has garnered significant interest from the organic
synthesis and medicinal chemistry communities. Herein, the synthesis of 2-(3, 3-difluoro-2 …
synthesis and medicinal chemistry communities. Herein, the synthesis of 2-(3, 3-difluoro-2 …
Brønsted acid-catalyzed enantioselective addition of 1, 3-diones to in situ generated N-acyl ketimines
MM Sadhu, SK Ray, RA Unhale… - Organic & Biomolecular …, 2022 - pubs.rsc.org
A Brønsted acid-catalyzed asymmetric Mannich-type addition of 1, 3-diones to cyclic N-acyl
ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl …
ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl …
Enantioselective construction of a tetrasubstituted stereocenter in isoindolinones via an organocatalyzed reaction between ketones and 3-hydroxyisoindolinones
M Matišić, M Gredičak - Chemical Communications, 2021 - pubs.rsc.org
An efficient enantioselective reaction between ketones and 3-hydroxyisoindolinones is
described. In a reaction catalyzed by a chiral phosphoric acid, a broad range of ketones and …
described. In a reaction catalyzed by a chiral phosphoric acid, a broad range of ketones and …
Enantioselective Bifunctional Ammonium Salt‐Catalyzed Syntheses of 3‐CF3S‐, 3‐RS‐, and 3‐F‐Substituted Isoindolinones
A Eitzinger, J Otevrel, V Haider… - Advanced Synthesis …, 2021 - Wiley Online Library
We herein report the ammonium salt‐catalyzed synthesis of chiral 3, 3‐disubstituted
isoindolinones bearing a heteroatom functionality in the 3‐position. A broad variety of …
isoindolinones bearing a heteroatom functionality in the 3‐position. A broad variety of …