Synapse organizers as molecular codes for synaptic plasticity
SA Connor, TJ Siddiqui - Trends in Neurosciences, 2023 - cell.com
Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …
processes of brain development and plasticity at the level of individual synapses. Their …
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus
Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …
Advances in neurexin studies and the emerging role of neurexin-2 in autism spectrum disorder
Over the past 3 decades, the prevalence of autism spectrum disorder (ASD) has increased
globally from 20 to 28 million cases making ASD the fastest-growing developmental …
globally from 20 to 28 million cases making ASD the fastest-growing developmental …
Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit
A Sclip, TC Südhof - Nature Communications, 2023 - nature.com
Synaptic adhesion molecules (SAMs) shape the structural and functional properties of
synapses and thereby control the information processing power of neural circuits. SAMs are …
synapses and thereby control the information processing power of neural circuits. SAMs are …
[HTML][HTML] Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism
α-and β-neurexins are extensively alternatively spliced, presynaptic cell-adhesion
molecules that are thought to organize synapse assembly. However, recent data revealed …
molecules that are thought to organize synapse assembly. However, recent data revealed …
Synaptic cell adhesion molecules contribute to the pathogenesis and progression of fragile X syndrome
SY Bai, DY Zeng, M Ouyang, Y Zeng… - Frontiers in Cellular …, 2024 - frontiersin.org
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a
monogenic cause of autism spectrum disorders. Deficiencies in the fragile X messenger …
monogenic cause of autism spectrum disorders. Deficiencies in the fragile X messenger …
Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures
Neurexins (Nrxns) have been extensively studied for their role in synapse organization and
have been linked to many neuropsychiatric disorders, including autism spectrum disorder …
have been linked to many neuropsychiatric disorders, including autism spectrum disorder …
Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease
M Martá-Ariza, DF Leitner, E Kanshin, J Suazo… - Acta …, 2025 - Springer
Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP
overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) …
overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) …
[HTML][HTML] Contrastsing synaptic roles of MDGA1 and MDGA2
Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing
molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 …
molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 …
New perspective on sustained antidepressant effect: focus on neurexins regulating synaptic plasticity
Y Ruan, R Yuan, J He, Y Jiang, S Chu, N Chen - Cell Death Discovery, 2024 - nature.com
Depression is highly prevalent globally, however, currently available medications face
challenges such as low response rates and short duration of efficacy. Additionally …
challenges such as low response rates and short duration of efficacy. Additionally …