The circadian nature of physiology and behavior is regulated by a circadian clock that
generates intrinsic rhythms with a periodicity of approximately 24 h. The mammalian …

The past twenty years have witnessed the most remarkable breakthroughs in our
understanding of the molecular and cellular mechanisms that underpin circadian …

Summary In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play.
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the
period of the mammalian circadian clock. Previous studies concluded that an unidentified …

Circadian clocks are timing systems that rhythmically adjust physiology and metabolism to
the 24-h day–night cycle. Eukaryotic circadian clocks are based on transcriptional …

Summary PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a
phosphoswitch that controls PER stability and repressive activity in the molecular clock …

Robust rhythms of abundances and phosphorylation profiles of PERIOD proteins were
thought be the master rhythms that drive mammalian circadian clock functions. PER stability …

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key
regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation …

CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their
misregulation contributes to cancer, neurodegenerative diseases, and sleep phase …

Unbiased drug target engagement deconvolution and mechanism of action elucidation are
major challenges in drug development. Modification-free target engagement methods, such …