Background: Redox signaling plays an important role in the lives of cells. This signaling not
only becomes apparent in pathologies but is also thought to be involved in maintaining …

The complex physiological signal transduction networks that respond to the dual challenges
of inflammatory and oxidative stress are major factors that promote the development of …

Abstract Aims Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular
outcomes, but the underlying mechanisms are still elusive. This study investigated the …

The mechanistic target of rapamycin complex-1 (mTORC1) coordinates regulation of growth,
metabolism, protein synthesis and autophagy. Its hyperactivation contributes to disease in …

Abstract Singlet molecular oxygen (1O2) has well-established roles in photosynthetic plants,
bacteria and fungi,–, but not in mammals. Chemically generated 1O2 oxidizes the amino …

Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Although low levels of reactive oxygen species (ROS) are beneficial for the organism
ensuring normal cell and vascular function, the overproduction of ROS and increased …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides.
While the 11 PDE subfamilies share common features, key differences confer signaling …

Sirt (Sirtuin) 7, the most recently identified mammalian sirtuin, has been shown to contribute
to appropriate wound healing processes after acute cardiovascular insult. However, its role …

Abstract Purpose of Review In highly prevalent cardiac diseases, new therapeutic
approaches are needed. Since the first description of oxidative stress in heart failure …