Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

BACKGROUND: Trials of β blockers in patients undergoing non-cardiac surgery have
reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 …

It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

These guidelines represent an update of those published in 1996 and are intended for
physicians who are involved in the preoperative, operative, and postoperative care of …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

Editor's note: This study was reviewed as part of a comprehensive investigation undertaken
by Erasmus Medical Center (Rotterdam, the Netherlands) into the scientific integrity of the …

The term ''adrenergic''originates from ''adrenaline''and describes hormones or drugs whose
effects are similar to those of epinephrine. Adrenergic stress is mediated by stimulation of …

It is essential that the medical profession play a significant role in critically evaluating the use
of diagnostic procedures and therapies as they are introduced and tested in the detection …

Introduction b-Blocker therapy plays a major role in the treatment of cardiovascular
diseases. For many years b-blockers were used for their antiischaemic, antiarryhthmic and …