The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Isothiocyanates (ITCs) are natural plant products generated by the enzymic hydrolysis of
glucosinolates found in Brassicaceae vegetables. These natural sulfur compounds and their …

Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating
resistance to toxic compounds in several life forms. In bacteria, these elements are involved …

Metal nanoparticles (MNPs) have recently gained extensive attention due to their broad-
spectrum prospect, particularly in biomedical application. Here, we reveal that long-term …

Drug efflux pumps transport antimicrobial agents out of bacteria, thereby reducing the
intracellular antimicrobial concentration, which is associated with intrinsic and acquired …

Pseudomonas aeruginosa biofilm is commonly associated with chronic wound infection. A
FDA approved wireless electroceutical dressing (WED), which in the presence of conductive …

The most abundant oxidants controlling bacterial colonization on mucosal barrier epithelia
are hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid …

Pseudomonas aeruginosa (Pae) is notorious for its high-level resistance toward clinically
used antibiotics. In fact, Pae has rendered most antimicrobials ineffective, leaving …

Multidrug-resistant mutants of Pseudomonas aeruginosa that overproduce the active efflux
system MexEF-OprN (called nfxC mutants) have rarely been characterized in the hospital …

Pseudomonas aeruginosa is among the most problematic opportunistic pathogens for adults
with cystic fibrosis (CF), causing repeated and resilient infections in the lung and …