Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration

S Baek, NTT Tran, DC Diaz, YY Tsai, JN Acedo… - Developmental cell, 2022 - cell.com
Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …

Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish

J Mi, KC Liu, O Andersson - Science Advances, 2023 - science.org
In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

Hair cell toxicology: with the help of a little fish

A Barrallo-Gimeno, J Llorens - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …

Advancements of ROS-based biomaterials for sensorineural hearing loss therapy

B Xu, Y Huang, D Yu, Y Chen - Biomaterials, 2024 - Elsevier
Sensorineural hearing loss (SNHL) represents a substantial global health challenge,
primarily driven by oxidative stress-induced damage within the auditory system. Excessive …

StaVia: spatially and temporally aware cartography with higher-order random walks for cell atlases

SV Stassen, M Kobashi, EY Lam, Y Huang, JWK Ho… - Genome Biology, 2024 - Springer
Single-cell atlases pose daunting computational challenges pertaining to the integration of
spatial and temporal information and the visualization of trajectories across large atlases …

An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish

N Denans, NTT Tran, ME Swall, DC Diaz… - Nature …, 2022 - nature.com
Macrophages are essential for tissue repair and regeneration. Yet, the molecular programs,
as well as the timing of their activation during and after tissue injury are poorly defined …

[HTML][HTML] Ultrack: pushing the limits of cell tracking across biological scales

J Bragantini, I Theodoro, X Zhao, TAPM Huijben… - …, 2024 - pmc.ncbi.nlm.nih.gov
Tracking live cells across 2D, 3D, and multi-channel time-lapse recordings is crucial for
understanding tissue-scale biological processes. Despite advancements in imaging …

Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo

EL Kozak, JR Miranda-Rodríguez, A Borges… - …, 2023 - journals.biologists.com
Collective cell rotations are widely used during animal organogenesis. Theoretical and in
vitro studies have conceptualized rotating cells as identical rigid-point objects that …

Skin ionocyte density of amphibious killifishes is shaped by phenotypic plasticity and constitutive interspecific differences

L Tunnah, AJ Turko, PA Wright - Journal of Comparative Physiology B, 2022 - Springer
When amphibious fishes are on land, gill function is reduced or eliminated and the skin is
hypothesized to act as a surrogate site of ionoregulation. Skin ionocytes are present in many …

Anion efflux mediates transduction in the hair cells of the zebrafish lateral line

ET Lunsford, YV Bobkov, BC Ray… - Proceedings of the …, 2023 - National Acad Sciences
Hair cells are the principal sensory receptors of the vertebrate auditory system, where they
transduce sounds through mechanically gated ion channels that permit cations to flow from …