Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Summary Activated effector T (TE) cells augment anabolic pathways of metabolism, such as
aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid …

Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger
selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Permanent residency in the eukaryotic cell pressured the prokaryotic mitochondrial ancestor
to strategize for intracellular living. Mitochondria are able to autonomously integrate and …

Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …

Mitochondrial architecture is involved in several functions crucial for cell viability,
proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the …

Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a
physiological process that impacts diverse cellular processes. Mitofusins are activated by …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …