Next-generation lineage tracing and fate mapping to interrogate development
Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
INTRODUCTION Cells and tissues are made up of diverse molecular building blocks,
organized with nanoscale precision over extended length scales. Newly developed …
organized with nanoscale precision over extended length scales. Newly developed …
Single-molecule analysis of nucleic acid biomarkers–A review
Nucleic acids are important biomarkers for disease detection, monitoring, and treatment.
Advances in technologies for nucleic acid analysis have enabled discovery and clinical …
Advances in technologies for nucleic acid analysis have enabled discovery and clinical …
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting
with hundreds of mRNA transcripts. However, miRNAs operate nonuniformly upon the …
with hundreds of mRNA transcripts. However, miRNAs operate nonuniformly upon the …
SCRINSHOT enables spatial mapping of cell states in tissue sections with single-cell resolution
A Sountoulidis, A Liontos, HP Nguyen, AB Firsova… - PLoS …, 2020 - journals.plos.org
Changes in cell identities and positions underlie tissue development and disease
progression. Although single-cell mRNA sequencing (scRNA-Seq) methods rapidly …
progression. Although single-cell mRNA sequencing (scRNA-Seq) methods rapidly …
HyPR-seq: single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes
JL Marshall, BR Doughty… - Proceedings of the …, 2020 - National Acad Sciences
Single-cell quantification of RNAs is important for understanding cellular heterogeneity and
gene regulation, yet current approaches suffer from low sensitivity for individual transcripts …
gene regulation, yet current approaches suffer from low sensitivity for individual transcripts …
SCRINSHOT, a spatial method for single-cell resolution mapping of cell states in tissue sections
A Sountoulidis, A Liontos, HP Nguyen, AB Firsova… - bioRxiv, 2020 - biorxiv.org
Abstract Changes in cell identities and positions underlie tissue development and disease
progression. Although, single-cell mRNA sequencing (scRNA-Seq) methods rapidly …
progression. Although, single-cell mRNA sequencing (scRNA-Seq) methods rapidly …
Fluorescent in situ sequencing of DNA barcoded antibodies
Biological tissues contain thousands of different proteins yet conventional antibody staining
can only assay a few at a time because of the limited number of spectrally distinct …
can only assay a few at a time because of the limited number of spectrally distinct …
Expansion microscopy imaging of various neuronal structures
Visualization of the spatial distribution of biomolecules with nanoscale precision is essential
to understanding the molecular mechanisms of biological phenomena and diseases. Among …
to understanding the molecular mechanisms of biological phenomena and diseases. Among …
Compositions and methods for light-directed biomolecular barcoding
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4, 5-dihydroxy-6-(phosphanyloxy) oxan-
3-yl] oxy}-4, 5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C (C …
3-yl] oxy}-4, 5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C (C …