Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Skeletal muscle mass and function tend to decline with increasing age. Insulin-like growth
factor 1 (IGF-1) plays a key role in promoting skeletal muscle growth. Exercise improves …

Long-duration mission (LDM) astronauts from the International Space Station (ISS)(> 180
ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) …

Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute
exercise introduces a multifaceted intracellular stress, with numerous post-translational …

Neurodegenerative diseases have multifactorial pathogenesis, mainly involving
neuroinflammatory processes. Finding drugs able to treat these diseases, expecially …

The discovery that contracting skeletal muscle generates reactive oxygen species (ROS)
was first reported over 40 years ago. The prevailing view in the 1980s was that exercise …

Skeletal muscle (SM) acts as a secretory organ, capable of releasing myokines and
extracellular vesicles (SM‐EVs) that impact myogenesis and homeostasis. While age …

Increased reactive oxygen species (ROS) generation and microvascular endothelial
disruptions occur with natural ageing, but often transpire before the detection of …