Big data, big knowledge: big data for personalized healthcare

M Viceconti, P Hunter, R Hose - IEEE journal of biomedical and …, 2015 - ieeexplore.ieee.org
The idea that the purely phenomenological knowledge that we can extract by analyzing
large amounts of data can be useful in healthcare seems to contradict the desire of VPH …

Diagnosis and management of osteomyelitis in children: a critical analysis review

AL Gornitzky, AE Kim, JM O'Donnell, I Swarup - JBJS reviews, 2020 - journals.lww.com
Diagnosis and Management of Osteomyelitis in Children: A Cri... : JBJS Reviews Diagnosis
and Management of Osteomyelitis in Children: A Critical Analysis Review : JBJS Reviews …

Network-based analysis of comorbidities risk during an infection: SARS and HIV case studies

MA Moni, P Liò - BMC bioinformatics, 2014 - Springer
Background Infections are often associated to comorbidity that increases the risk of medical
conditions which can lead to further morbidity and mortality. SARS is a threat which is similar …

Staphylococcus aureus infects osteoclasts and replicates intracellularly

JL Krauss, PM Roper, A Ballard, CC Shih… - MBio, 2019 - Am Soc Microbiol
Osteomyelitis (OM), or inflammation of bone tissue, occurs most frequently as a result of
bacterial infection and severely perturbs bone structure. OM is predominantly caused by …

comoR: a software for disease comorbidity risk assessment

MA Moni, P Liò - Journal of clinical bioinformatics, 2014 - Springer
Background The diagnosis of comorbidities, which refers to the coexistence of different
acute and chronic diseases, is difficult due to the modern extreme specialisation of …

The role of osteocytes in targeted bone remodeling: a mathematical model

JM Graham, BP Ayati, SA Holstein, JA Martin - PloS one, 2013 - journals.plos.org
Until recently many studies of bone remodeling at the cellular level have focused on the
behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the …

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

C Yuan, XT Yu, J Wang, B Shu, XY Wang, C Huang… - Cell Discovery, 2024 - nature.com
Due to a rapidly aging global population, osteoporosis and the associated risk of bone
fractures have become a wide-spread public health problem. However, osteoporosis is very …

The effects of osteoporotic and non-osteoporotic medications on fracture risk and bone mineral density

AC van der Burgh, CE de Keyser, MC Zillikens… - Drugs, 2021 - Springer
Osteoporosis is a highly prevalent bone disease affecting more than 37.5 million individuals
in the European Union (EU) and the United States of America (USA). It is characterized by …

Cocktail of isobavachalcone and curcumin enhance eradication of Staphylococcus aureus biofilm from orthopedic implants by gentamicin and alleviate inflammatory …

Y Chen, H Hu, F Huang, Z Ling, B Chen, B Tan… - Frontiers in …, 2022 - frontiersin.org
Orthopedic device-related infection (ODRI) caused by Staphylococcus aureus, especially
methicillin-resistant S. aureus (MRSA) biofilm may lead to persist infection and severe …

Network regularised cox regression and multiplex network models to predict disease comorbidities and survival of cancer

H Xu, MA Moni, P Liò - Computational biology and chemistry, 2015 - Elsevier
In cancer genomics, gene expression levels provide important molecular signatures for all
types of cancer, and this could be very useful for predicting the survival of cancer patients …