Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with
pleiotropic functions in the human body. Elevated fasting blood BCAA concentrations are …

EAA-BCAA balanced supplements might be valuable not only for healthy individuals
undergoing to energy deficit (eg, athletes) during strenuous exercise or training but also …

Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …

Background Polycystic ovary syndrome (PCOS) is one of the most common diseases with
the coexistence of reproductive malfunction and metabolic disorders. Previous studies have …

Exosomes are promising therapeutics for tissue repair and regeneration to induce and guide
appropriate immune responses in dystrophic pathologies. However, manipulating exosomes …

Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to
adaptive metabolic responses. Yet, how such functionally relevant protein acetylation is …

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the
production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor …

While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play
a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP …

Simple Summary Cancer is a global health problem with high personal and economic
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …