Aging-Oxidative stress, antioxidants and computational modeling

F Hussain, HUR Kayani - Heliyon, 2020 - cell.com
Aging is a degenerative, biological, time-dependent, universally conserved process thus
designed as one of the highest known risk factors for morbidity and mortality. Every …

Wash-free detection and bioimaging by AIEgens

X Huang, R Zhang, C Chen, RTK Kwok… - Materials Chemistry …, 2021 - pubs.rsc.org
Wash-free fluorescence detection and bioimaging has attracted increasing attention as it
can largely simplify the analytical procedure, significantly shorten the detection time, and …

Mitochondrial dysfunction in aging and diseases of aging

RH Haas - Biology, 2019 - mdpi.com
Mitochondria have been increasingly recognized as the important players in the aging
process. Most aging-related diseases, particularly, neurodegenerative diseases, have …

The endoplasmic reticulum stress and the unfolded protein response in kidney disease: Implications for vascular growth factors

CA Ricciardi, L Gnudi - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
Acute kidney injury (AKI) and chronic kidney disease (CKD) represent an important
challenge for healthcare providers. The identification of new biomarkers/pharmacological …

Increased mitochondrial content and function by resveratrol and select flavonoids protects against benzo [a] pyrene-induced bioenergetic dysfunction and ROS …

K Omidian, H Rafiei, B Bandy - Free Radical Biology and Medicine, 2020 - Elsevier
Dietary polyphenols act in cancer prevention and may inhibit carcinogenesis. A possible
mitochondrial mechanism for carcinogen-induced neoplastic transformation and …

Mitochondrial dysfunction: a key player in brain aging and diseases

S Bartman, G Coppotelli, JM Ross - Current Issues in Molecular Biology, 2024 - mdpi.com
Mitochondria are thought to have become incorporated within the eukaryotic cell
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …

Incomplete healing as a cause of aging: the role of mitochondria and the cell danger response

RK Naviaux - Biology, 2019 - mdpi.com
The rate of biological aging varies cyclically and episodically in response to changing
environmental conditions and the developmentally-controlled biological systems that sense …

Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging

MF Montaron, V Charrier, N Blin, P Garcia… - Aging cell, 2020 - Wiley Online Library
During aging, some individuals are resilient to the decline of cognitive functions whereas
others are vulnerable. These inter‐individual differences in memory abilities have been …

Mitochondrial involvement in the adaptive response to chronic exposure to environmental pollutants and high-fat feeding in a rat liver and testis

V Migliaccio, I Di Gregorio, R Putti, L Lionetti - Cells, 2019 - mdpi.com
In our modern society, exposure to stressful environmental stimuli, such as pollutants and/or
chronic high-fat feeding, continuously induce tissular/organ metabolic adaptation to promote …

[HTML][HTML] HIF-1α protects nucleus pulposus cells from oxidative stress-induced mitochondrial impairment through PDK-1

Z Liu, J Zheng, T Ding, H Chen, R Wan, X Zhang… - Free Radical Biology …, 2024 - Elsevier
The pathogenesis of intervertebral disc degeneration (IVDD) involves complex signaling
networks and various effector molecules, and our understanding of the pathogenesis of …