[HTML][HTML] Strategies to prolong the residence time of drug delivery systems on ocular surface

B Grassiri, Y Zambito, A Bernkop-Schnürch - Advances in colloid and …, 2021 - Elsevier
Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …

The use of preservatives in dry eye drops

K Walsh, L Jones - Clinical Ophthalmology, 2019 - Taylor & Francis
Topical ocular preparations are widely recommended by health care professionals, or
chosen by patients, to help manage dry eye disease (DED). The chronic and progressive …

Topical sustained drug delivery to the retina with a drug-eluting contact lens

AE Ross, LC Bengani, R Tulsan, DE Maidana… - Biomaterials, 2019 - Elsevier
Intravitreal injections and implants are used to deliver drugs to the retina because
therapeutic levels of these medications cannot be provided by topical administration (ie eye …

Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery

Q Wang, Z Zuo, CKC Cheung, SSY Leung - International Journal of …, 2019 - Elsevier
Thermosensitive hydrogels are in situ gelling systems composed of hydrophilic
homopolymers or block copolymers which remain as solutions at room temperature and …

Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye

Y Wu, LK Vora, RF Donnelly, TRR Singh - Drug Delivery and Translational …, 2023 - Springer
The discovery of proteins that neutralise vascular endothelial growth factors, such as
pegaptanib, ranibizumab and aflibercept, can inhibit the process of angiogenesis, thereby …

Nanoparticles-hydrogel composites: A promising innovative system for local antimicrobial applications

DT Pham, K Navesit, L Wiwatkunupakarn… - Journal of Drug Delivery …, 2023 - Elsevier
Local infectious diseases are disorders caused by a pathogen such as bacteria, fungi, virus,
and protozoa that common occur in the eyes, oral cavity, bone, and skin. Recently, the …

Novel approaches for imaging-based diagnosis of ocular surface disease

D Schmidl, A Schlatter, J Chua, B Tan, G Garhöfer… - Diagnostics, 2020 - mdpi.com
Imaging has become indispensable in the diagnosis and management of diseases in the
posterior part of the eye. In recent years, imaging techniques for the anterior segment are …

The emerging role of topical ocular drugs to target the posterior eye

L Wang, MB Zhou, H Zhang - Ophthalmology and Therapy, 2021 - Springer
The prevalence of chronic fundus diseases is increasing with the aging of the general
population. The treatment of these intraocular diseases relies on invasive drug delivery …

The prominence of the dosage form design to treat ocular diseases

PM Campos, R Petrilli, RFV Lopez - International Journal of Pharmaceutics, 2020 - Elsevier
The eye is susceptible to various diseases commonly difficult to treat. To overcome the
barriers imposed by this organ for required drugs penetration, technological strategies have …

[HTML][HTML] A polymeric aqueous tacrolimus formulation for topical ocular delivery

MY Badr, NS Abdulrahman, AG Schatzlein… - International journal of …, 2021 - Elsevier
Tacrolimus (TAC) suspension is used to treat moderate to severe atopic keratoconjunctivitis
(AKC) and vernal keratoconjunctivitis (VKC). The objectives of this study were to formulate …