Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

BACKGROUND: Posttranslational modifications (PTMs) greatly expand the function and
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …

Alterations of the structure and composition of cardio-myocyte and noncardiomyocyte
compartments of the myocardium appear to play a central role in the pathogenesis of heart …

Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness
correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins …

We previously found an inverse relationship between sialidase Neu1 expression and
metastatic potential of murine cancer cells. To elucidate the mechanism underlying the …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Real‐time imaging of cell‐surface‐associated proteolytic enzymes is critical to better
understand their performances in both physiological and pathological processes. However …

Herpesviruses are among the most complex and widespread viruses, infection and
propagation of which depend on envelope proteins. These proteins serve as mediators of …

GalNAc‐type O‐glycosylation and its initiating GalNAc transferases (GALNTs) play crucial
roles in a wide range of cellular behaviors. Among 20 GALNT members, GALNT2 is …