Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Environmental insults impair human health around the world. Contaminated air, water, soil,
food, and occupational and household settings expose humans of all ages to a plethora of …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

The key issue in the treatment of solid tumors is the lack of efficient strategies for the targeted
delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) …

Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

STUDY QUESTION Are there age-related differences in gene expression during the
germinal vesicle (GV) to metaphase II (MII) stage transition in euploid human oocytes …

Senescence is a unique state of growth arrest that develops in response to a plethora of
cellular stresses, including replicative exhaustion, oxidative injury, and genotoxic insults …

Histone acetylations are important epigenetic markers for transcriptional activation in
response to metabolic changes and various stresses. Using the high-throughput …

ABSTRACT DNA molecules are highly compacted in the eukaryotic nucleus where distal
regulatory elements reach their targets through three-dimensional chromosomal …

Acute myeloid leukemia (AML) is an aggressive hematological disorder mainly affecting
people of older age. AML initiation is primarily attributed to mutations in crucial cellular …