The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

AP Voigt, K Mulfaul, NK Mullin… - Proceedings of the …, 2019 - National Acad Sciences
The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide
crucial support to the retina. Disease affecting either of these supportive tissues can lead to …

Age-related macular degeneration

M Fleckenstein, TDL Keenan, RH Guymer… - Nature reviews Disease …, 2021 - nature.com
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies

CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

The challenges and promise of complement therapeutics for ocular diseases

DH Park, KM Connor, JD Lambris - Frontiers in Immunology, 2019 - frontiersin.org
Ocular inflammation is a defining feature of sight threating diseases and its dysregulation
can catalyze and or propagate ocular neurodegenerative maladies such as age-related …

Senescence in the pathogenesis of age-related macular degeneration

J Blasiak - Cellular and Molecular Life Sciences, 2020 - Springer
Age-related macular degeneration (AMD) is a complex eye disease underlined by the death
of photoreceptors and degeneration of retinal pigment epithelium (RPE) and choriocapillaris …

Age-related macular degeneration: A two-level model hypothesis

MP Rozing, JA Durhuus, MK Nielsen, Y Subhi… - Progress in retinal and …, 2020 - Elsevier
Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …

[HTML][HTML] Stemming retinal regeneration with pluripotent stem cells

ZB Jin, ML Gao, WL Deng, KC Wu, S Sugita… - Progress in retinal and …, 2019 - Elsevier
Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Measuring the contributions of basal laminar deposit and Bruch's membrane in age-related macular degeneration

AA Sura, L Chen, JD Messinger… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: Basal laminar deposit (BLamD) is a consistent finding in age-related macular
degeneration (AMD). We quantified BLamD thickness, appearance, and topography in eyes …