Pathophysiology of portal hypertension

Y Iwakiri, RJ Groszmann - The Liver: Biology and Pathobiology, 2020 - Wiley Online Library
The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

The current management of hepatorenal syndrome–acute kidney injury in the United States and the potential of terlipressin

SL Flamm, K Brown, HM Wadei… - Liver …, 2021 - Wiley Online Library
Acute kidney injury (AKI) in the setting of cirrhosis (hepatorenal syndrome [HRS]–AKI) is a
severe and often fatal complication of end‐stage liver disease. The goals of treatment are to …

Biology of portal hypertension

M McConnell, Y Iwakiri - Hepatology international, 2018 - Springer
Portal hypertension develops as a result of increased intrahepatic vascular resistance often
caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular …

Renal function in cirrhosis: a critical review of available tools

S Piano, A Brocca, P Angeli - Seminars in Liver Disease, 2018 - thieme-connect.com
Patients with cirrhosis have a high prevalence of renal dysfunction. The susceptibility to
renal dysfunction is due to both the severe splanchnic arterial vasodilation and the systemic …

Management of liver failure in general intensive care unit

C Paugam-Burtz, E Levesque, A Louvet… - … Critical Care & Pain …, 2020 - Elsevier
Abstract Objective To produce French guidelines on Management of Liver failure in general
Intensive Care Unit (ICU). Design A consensus committee of 23 experts from the French …

Inpatient mortality benefit with transjugular intrahepatic portosystemic shunt for hospitalized hepatorenal syndrome patients

P Charilaou, K Devani, R Petrosyan, C Reddy… - Digestive diseases and …, 2020 - Springer
Background It has been reported that transjugular intrahepatic portosystemic shunting
(TIPS) might be utilized as a salvage option for hepatorenal syndrome (HRS), while …

The burden of illness of hepatorenal syndrome (HRS) in the United States: a retrospective analysis of electronic health records

K Jamil, X Huang, B Lovelace, AT Pham… - Journal of medical …, 2019 - Taylor & Francis
Abstract Objectives: Hepatorenal Syndrome (HRS) is characterized by renal failure in
patients with advanced chronic liver disease (CLD) and is the leading cause of …

Pharmacologic management of portal hypertension

C Bunchorntavakul, KR Reddy - Clinics in liver disease, 2019 - liver.theclinics.com
Portal hypertension (PHT) is the major driver for most complications of cirrhosis leading to
death or liver transplantation, for example, variceal hemorrhage (VH), ascites, and the …

Hepatorenal syndrome in cirrhosis: diagnostic, pathophysiological, and therapeutic aspects

TM Busk, F Bendtsen, S Møller - Expert review of gastroenterology …, 2016 - Taylor & Francis
Introduction: Renal failure is a common and serious complication in cirrhosis and represents
a wide spectrum of etiologies. The hepatorenal syndrome (HRS) represents a distinct type of …

Urinary cell cycle arrest biomarker [TIMP-2]·[IGFBP7] in patients with hepatorenal syndrome

CC Zhang, DAA Hoffelt, U Merle - Biomarkers, 2019 - Taylor & Francis
Background: Patients with hepatorenal syndrome carry a high short-term mortality. Early
diagnosis and treatment are essential for patients' outcome. Nevertheless diagnosis of HRS …