The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain
and gastrointestinal (GI) system. SST is produced in various organs and cells, and the …

The mechanisms underlying obesity-induced insulin resistance remain incompletely
understood, as impaired cellular insulin signaling, traditionally considered the primary driver …

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin
from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate …

Glucose homeostasis is maintained by the glucoregulatory hormones, glucagon, insulin and
somatostatin, secreted from the islets of Langerhans. Glucagon is the body's most important …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

The interactions among diet, intestinal immunity, and microbiota are complex and play
contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies …

While pancreatic β and α cells are considered the main drivers of blood glucose
homeostasis through insulin and glucagon secretion, the contribution of δ cells and …

Pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells,
which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the …