Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

Gout is an inflammatory condition caused by elevated serum urate (SU), a condition known
as hyperuricemia (HU). Genetic variations, including single nucleotide polymorphisms …

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is
known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation …

Sex differences have been widely observed in human health. However, little is known about
the underlying mechanism behind these observed sex differences. We hypothesize that sex …

The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed
by the deposition of monosodium urate crystal in articular structures and culminating in an …

Objectives To perform a genome-wide association study (GWAS) of gout cases versus
asymptomatic hyperuricaemia (AH) controls, and gout cases versus normouricaemia …

Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also
increases the incidence of many other conditions including renal disease, cardiovascular …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Background While genome-wide associations studies (GWAS) have successfully elucidated
the genetic architecture of complex human traits and diseases, understanding mechanisms …

Gout is a chronic metabolic disease that seriously affects human health. It is also a major
challenge facing the world, which has brought a heavy burden to patients and society …