No common malignancy is as rapidly and inevitably fatal as pancreatic ductal
adenocarcinoma (PDA). This grim fact has driven substantial research efforts into this …

Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a
cytoskeletal crosslinker and signaling scaffold, affecting mechanical as well as dynamic …

International experts met to discuss recent advances and to revise the 2004
recommendations for assessing and reporting precursor lesions to invasive carcinomas of …

Tumor cell–derived extracellular vesicles (EVs) are being explored as circulating
biomarkers, but it is unclear whether bulk measurements will allow early cancer detection …

Background: There are no established guidelines for pathologic diagnosis/reporting of
intraductal papillary mucinous neoplasms (IPMNs). Design: An international …

Background and Aims Advances in cross-sectional imaging have resulted in increased
detection of intraductal papillary mucinous neoplasms (IPMNs), and their management …

Plectin, a giant multifunctional cytolinker protein, plays a crucial role in stabilizing and
orchestrating intermediate filament networks in cells. Mutations in the human plectin gene …

Esophageal squamous cell carcinoma (ESCC) is among the top ten most frequent
malignancies worldwide. In this study, our objective was to identify potential biomarkers for …

The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant
hallmarks in many human cancers due to its involvement in various cellular activities …

Effective new therapies for pancreatic ductal adenocarcinoma (PDAC) are desperately
needed as the prognosis of PDAC patients is dismal and treatment remains a major …