Non-protein-coding transcripts have been conserved throughout evolution, indicating that
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of
56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990s when …

Genome integrity must be tightly preserved to ensure cellular survival and to deter the
genesis of disease. Endogenous and exogenous stressors that impose threats to genomic …

Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs)
and small non-coding RNAs (eg, microRNAs) that bind to distinct elements in their mRNA …

Proteins and RNA interaction have vital roles in many cellular processes such as protein
synthesis, sequence encoding, RNA transfer, and gene regulation at the transcriptional and …

Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and
nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to …

The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …