Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …

In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

The recent development of spatial omics methods has enabled single-cell profiling of the
transcriptome and 3D genome organization with high spatial resolution. Expanding the …

Human cortex transcriptomic studies have revealed a hierarchical organization of γ-
aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of …

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision
access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in …