Immunological mechanisms involved in macrophage activation and polarization in schistosomiasis

ICL Licá, GCCG Frazão, RA Nogueira, MGS Lira… - Parasitology, 2023 - cambridge.org
Human schistosomiasis is caused by helminths of the genus Schistosoma. Macrophages
play a crucial role in the immune regulation of this disease. These cells acquire different …

The role of IL-17-producing cells in cutaneous fungal infections

Y Sawada, A Setoyama, Y Sakuragi… - International Journal of …, 2021 - mdpi.com
The skin is the outermost layer of the body and is exposed to many environmental stimuli,
which cause various inflammatory immune responses in the skin. Among them, fungi are …

Extracellular Vesicles from Aspergillus flavus Induce M1 Polarization In Vitro

VS Brauer, AM Pessoni, TA Bitencourt, RG de Paula… - Msphere, 2020 - Am Soc Microbiol
Aspergillus flavus, a ubiquitous and saprophytic fungus, is the second most common cause
of aspergillosis worldwide. Several mechanisms contribute to the establishment of the fungal …

Extracellular vesicles from Paracoccidioides brasiliensis induced M1 polarization in vitro

TA Da Silva, MC Roque-Barreira, A Casadevall… - Scientific reports, 2016 - nature.com
Extracellular vesicles (EVs) released by eukaryotes, archaea, and bacteria contain proteins,
lipids, polysaccharides, and other molecules. The cargo analysis of EVs shows that they …

Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration

RJ Krawetz, S Abubacker, C Leonard… - NPJ Regenerative …, 2022 - nature.com
The wound healing response is one of most primitive and conserved physiological
responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the …

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

A Sardinha-Silva, FC Mendonça-Natividade… - PLoS …, 2019 - journals.plos.org
Infection of host cells by Toxoplasma gondii is an active process, which is regulated by
secretion of microneme (MICs) and rhoptry proteins (ROPs and RONs) from specialized …

LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR …

D Bai, Y Zhao, Q Zhu, Y Zhou, Y Zhao, T Zhang… - Experimental cell …, 2018 - Elsevier
Macrophage polarization is involved in the process of inflammation. Regulation of
macrophage polarization is considered to be an effective method for the treatment of various …

Extracellular vesicles from Candida albicans modulate immune cells function and play a protective role in fungal keratitis

H Duan, F Meng, X Liu, P Qi, X Peng, C Li, Q Wang… - Microbial …, 2024 - Elsevier
Fungal keratitis (FK) is a highly blinding infectious corneal disease caused by pathogenic
fungi. Candida albicans (C. albicans) is one of the main pathogens of fungal keratitis …

MicroRNA-301a inhibition enhances the immunomodulatory functions of adipose-derived mesenchymal stem cells by induction of macrophage M2 polarization

LW Hsu, KT Huang, T Nakano… - International journal …, 2020 - journals.sagepub.com
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a significant role in
biological processes in various cell types, including mesenchymal stem cells (MSCs) …

Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis

J Mattke, CM Darden, MC Lawrence, J Kuncha… - Frontiers in …, 2024 - frontiersin.org
Acute pancreatitis is a complex inflammatory disease resulting in extreme pain and can
result in significant morbidity and mortality. It can be caused by several factors ranging from …