Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …

Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Actin depolymerizing factor (ADF) and cofilin accelerate actin dynamics by severing and
disassembling actin filaments. Here, we present the 3.8 Å resolution cryo-EM structure of …

In solid tumors, tumor invasion and metastasis account for 90% of cancer‐related deaths.
Cell migration is steered by the lamellipodia formed at the leading edge. These lamellipodia …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Summary Actin-depolymerizing factor (ADF)/cofilins contribute to cytoskeletal dynamics by
promoting rapid actin filament disassembly. In the classical view, ADF/cofilin sever filaments …