Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

Platelets are the main cellular component in blood responsible for maintaining the integrity
of the cardiovascular system via hemostasis. Platelet dysfunction contributes to a wide range …

Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in
cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections …

The glycome acts as an essential interface between cells and the surrounding
microenvironment. However, changes in glycosylation occur in nearly all breast cancers …

The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans
(CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed …

Metastasis is responsible for the majority of breast cancer-related deaths. The metastatic
spread of cancer cells is a complicated process that requires considerable flexibility in the …

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

Chondroitin sulfate-hybridized zein nanoparticles (zein/CS NPs) were developed for
targeted delivery of docetaxel, which exhibited mean diameters of 157.8±3.6 nm and …