Effects of early-life stress on the brain and behaviors: implications of early maternal separation in rodents

M Nishi - International journal of molecular sciences, 2020 - mdpi.com
Early-life stress during the prenatal and postnatal periods affects the formation of neural
networks that influence brain function throughout life. Previous studies have indicated that …

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives

M Rincel, M Darnaudéry - Proceedings of the Nutrition Society, 2020 - cambridge.org
The developmental period constitutes a critical window of sensitivity to stress. Indeed, early-
life adversity increases the risk to develop psychiatric diseases, but also gastrointestinal …

Effect of early maternal separation stress on attention, spatial learning and social interaction behaviour

MY Kambali, K Anshu, BM Kutty… - Experimental brain …, 2019 - Springer
Early life stress is known to influence affective and cognitive functions in later life but
comprehensive explanation for the impact of early life stress on attentional functions …

Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences

LR Halladay, SM Herron - Neuropharmacology, 2023 - Elsevier
Nearly one percent of children in the US experience childhood neglect or abuse, which can
incite lifelong emotional and behavioral disorders. Many studies investigating the neural …

Effects of early life adversities upon memory processes and cognition in rodent models

J Alves, N de Sá Couto-Pereira, RMS de Lima… - Neuroscience, 2022 - Elsevier
Exposure to stressors in early postnatal life induces long-lasting modifications in brain
function. This plasticity, an essential characteristic of the brain that enables adaptation to the …

[HTML][HTML] Early maternal separation alters the activation of stress-responsive brain areas in adulthood

DRC Fóscolo, PMA Lima, GV Rodovalho… - Neuroscience …, 2022 - Elsevier
The expression of c-Fos protein has been extensively used as a marker of neuronal
activation in response to stressful stimuli. Early maternal separation (MS) is a model of early …

Beneficial effect of saturated and poly-unsaturated fat-rich diet on risky decision-making behaviour in adolescent rats exposed to early-life stress

A Chowdhury, BSS Rao, TR Laxmi - Physiology & Behavior, 2025 - Elsevier
Previous studies suggest that early-life stress (ELS) induced by early maternal separation
and isolation (MS) stress during the stress hyporesponsive period (SHRP) leads to …

Early maternal and social deprivation expands neural stem cell population size and reduces hippocampus/amygdala-dependent fear memory

KA Daun, T Fuchigami, N Koyama, N Maruta… - Frontiers in …, 2020 - frontiersin.org
Early life stress can exert detrimental or beneficial effects on neural development and
postnatal behavior depending on the timing, duration, strength, and ability to control the …

Impacts of linseed oil diet on anxiety and memory extinction after early life stress: A sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and …

RA Caetano, J Alves, TA Smaniotto, FD Dutra… - Brain Research, 2025 - Elsevier
Early exposure to stressors affects how the organism reacts to stimuli, its emotional state
throughout life, and how it deals with emotional memories. Consequently, it may affect …

Effects of early life stress during stress hyporesponsive period (SHRP) on anxiety and curiosity in adolescent rats

SS Sharma, MM Srinivas Bharath… - Experimental Brain …, 2022 - Springer
Repeated exposure to adverse experiences in early life, termed Early Life Stress (ELS), can
increase anxiety disorders later in life. Anxiety is directly associated with curiosity, a form of …