Treating chronic diseases without tackling excess adiposity promotes multimorbidity

N Sattar, JJV McMurray, IB McInnes… - The lancet Diabetes & …, 2023 - thelancet.com
Few people now reach old age without taking multiple drugs, often attending various clinics,
and undergoing secondary or tertiary investigations. Most chronic conditions are, to differing …

The impact of obesity: a narrative review

BCC Lam, AYL Lim, SL Chan, MPS Yum… - Singapore medical …, 2023 - journals.lww.com
Obesity is a disease with a major negative impact on human health. However, people with
obesity may not perceive their weight to be a significant problem and less than half of …

Physiological and environmental factors affecting cancer risk and prognosis in obesity

PFS Etet, L Vecchio, AHN Kamdje, PN Mimche… - Seminars in Cancer …, 2023 - Elsevier
Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term
imbalance between energy intake and expenditure. Available epidemiological and clinical …

Causal factors for Osteoarthritis: a scoping review of mendelian randomization studies

E Alhassan, K Nguyen, MC Hochberg… - Arthritis Care & …, 2024 - Wiley Online Library
Objective Mendelian randomization (MR) has increasingly been utilized as a tool for
establishing causal relations between modifiable exposures and osteoarthritis (OA). The …

[HTML][HTML] Mendelian randomization studies in psoriasis and psoriatic arthritis: a systematic review

JQ Jin, KG Elhage, RK Spencer, MS Davis… - Journal of Investigative …, 2023 - Elsevier
Psoriasis (PSO) and psoriatic arthritis (PSA) are inflammatory diseases with complex genetic
and environmental contributions. Although studies have identified environmental and …

Mendelian randomization supports the causal role of fasting glucose on periodontitis

Y Wang, T Chu, Y Gong, S Li, L Wu, L Jin… - Frontiers in …, 2022 - frontiersin.org
Purpose The effect of hyperglycemia on periodontitis is mainly based on observational
studies, and inconsistent results were found whether periodontal treatment favors glycemic …

Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study

V Karageorgiou, F Casanova, J O'Loughlin, H Green… - BMC medicine, 2023 - Springer
Background Major depressive disorder (MDD) has a significant impact on global burden of
disease. Complications in clinical management can occur when response to …

[HTML][HTML] Waist-to-height ratio and body fat percentage as risk factors for ischemic cardiovascular disease: a prospective cohort study from UK Biobank

Q Feng, J Bešević, M Conroy, W Omiyale… - The American Journal of …, 2024 - Elsevier
Background The independent effect of waist-to-height ratio (WHtR) and body fat percentage
(BF%) on ischemic cardiovascular disease (CVD) remains uncertain. Objectives This study …

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation

GM Leyden, MP Greenwood, V Gaborieau… - British Journal of …, 2023 - nature.com
Background Body mass index (BMI) is known to influence the risk of various site-specific
cancers, however, dissecting which subcomponents of this heterogenous risk factor are …

MSI2 Modulates Unsaturated Fatty Acid Metabolism by Binding FASN in Bovine Mammary Epithelial Cells

CC Lyu, Y Meng, HY Che, JL Suo, YT He… - Journal of Agricultural …, 2023 - ACS Publications
The regulation of fatty acid metabolism is crucial for milk flavor and quality. Therefore, it is
important to explore the genes that play a role in fatty acid metabolism and their …