Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
G-quadruplex-forming aptamers—characteristics, applications, and perspectives
C Roxo, W Kotkowiak, A Pasternak - Molecules, 2019 - mdpi.com
G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects
C Riccardi, E Napolitano, C Platella… - Pharmacology & …, 2021 - Elsevier
First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …
Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter
MT Murray, SD Wetmore - Nucleic Acids Research, 2024 - academic.oup.com
The thrombin binding aptamer (TBA) is a prototypical platform used to understand the impact
of chemically-modified nucleotides on aptamer stability and target affinity. To provide …
of chemically-modified nucleotides on aptamer stability and target affinity. To provide …
Label-free electrochemical aptasensor for ultrasensitive thrombin detection using graphene nanoplatelets and carbon nano onion-based nanocomposite
Thrombin (TB) is a protease enzyme functioning in the blood coagulation cascade. It plays
an important function in a number of diseases, including thromboembolic disease …
an important function in a number of diseases, including thromboembolic disease …
Strategies to bioengineer aptamer-driven nanovehicles as exceptional molecular tools for targeted therapeutics: A review
Aptamers are a class of folded nucleic acid strands capable of binding to different target
molecules with high affinity and selectivity. Over the years, they have gained a substantial …
molecules with high affinity and selectivity. Over the years, they have gained a substantial …
Fluorescent thrombin binding aptamer-tagged nanoparticles for an efficient and reversible control of thrombin activity
Progress in understanding and treatment of thrombotic diseases requires new effective
methods for the easy, rapid, and reversible control of coagulation processes. In this …
methods for the easy, rapid, and reversible control of coagulation processes. In this …
Conformational deviation of Thrombin binding G-quadruplex aptamer (TBA) in presence of divalent cation Sr2+: A classical molecular dynamics simulation study
Thrombin binding TBA-G-quadruplex aptamer (TBA) plays a major role in blood coagulation
cascade. The 15-mer TBA sequence tends to form four-stranded TBA-G-quadruplex …
cascade. The 15-mer TBA sequence tends to form four-stranded TBA-G-quadruplex …
Construction of a bivalent thrombin binding aptamer and its antidote with improved properties
Aptamers are short synthetic DNA or RNA oligonucleotides that adopt secondary and tertiary
conformations based on Watson–Crick base-pairing interactions and can be used to target a …
conformations based on Watson–Crick base-pairing interactions and can be used to target a …
An aptasensor based on heparin-mimicking hyperbranched polyester with anti-biofouling interface for sensitive thrombin detection
In this paper, novel heparin-mimicking hyperbranched polyester nanoparticles (HBPE-SO 3
NPs) with abundant of sulfonated acid functional groups were synthesized, and their …
NPs) with abundant of sulfonated acid functional groups were synthesized, and their …