Abstract Ethnopharmacological relevance Radix Rehmanniae (RR) is the tuber root of
Rehmannia glutionsa Libosch, which was firstly recorded in Shennong's Classic of Materia …

Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay is a long-
established assay used to detect cell death-associated DNA fragmentation (3'-OH DNA …

The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …

Background and Purpose Oxidative stress and neuronal apoptosis play key roles in
traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic …

Sepsis-associated encephalopathy (SAE) is one of the common serious complications in
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …

The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried
root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a …

Sepsis is a common risk factor for acute kidney injury (AKI). Bone marrow-derived
mesenchymal stem cells (BMSCs) bear multi-directional differentiation potential. This study …

This study evaluated if the hepatic protective effect of Isoliquiritigenin (ISL) against
doxorubicin (DOX)-treated rats involves upregulating sirtuin-1 (SIRT1) signaling. Adult male …

Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily
obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very …

Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide
population, and causing long-term troubles to the patients. Therefore, it is urgent to develop …