The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized
filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately …

The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote …

With the refinement of algorithms for the identification of distinct motifs from sequence
databases, especially those using secondary structure predictions, new protein modules …

The actin cytoskeleton plays a central role in many cell biological processes. The structure
and dynamics of the actin cytoskeleton are regulated by numerous actin-binding proteins …

The dermal‐epidermal junction consists of a network of several interacting structural
proteins that strengthen adhesion and mediate signalling events. This structural network …

Paxillin is a focal adhesion adapter protein involved in the integration of growth factor–and
adhesion-mediated signal transduction pathways. Paxillin LD motifs have been …

Background: Dystrophin is an essential component of skeletal muscle cells. Its N-terminal
domain binds to F-actin and its C terminus binds to the dystrophin-associated glycoprotein …

Smooth muscle cells possess a structural lattice composed of two primary parts: the
'cytoskeleton'that pervades the cytoplasm and the 'membrane skeleton'that provides …

Most mutations that truncate the reading frame of the DMD gene cause loss of dystrophin
expression and lead to Duchenne muscular dystrophy. However, amelioration of disease …