Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Emerging roles and functional mechanisms of PIWI-interacting RNAs

X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

PIWI-interacting RNAs: small RNAs with big functions

DM Ozata, I Gainetdinov, A Zoch, D O'Carroll… - Nature Reviews …, 2019 - nature.com
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …

CPC2: a fast and accurate coding potential calculator based on sequence intrinsic features

YJ Kang, DC Yang, L Kong, M Hou… - Nucleic acids …, 2017 - academic.oup.com
With advances in next-generation sequencing technologies, numerous novel transcripts in a
large number of organisms have been identified. With the goal of fast, accurate assessment …

piRNA-guided genome defense: from biogenesis to silencing

B Czech, M Munafò, F Ciabrelli… - Annual review of …, 2018 - annualreviews.org
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …

Functions and mechanisms of epigenetic inheritance in animals

K Skvortsova, N Iovino, O Bogdanović - Nature reviews Molecular cell …, 2018 - nature.com
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

RNA-mediated epigenetic regulation of gene expression

D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Transgenerational epigenetic inheritance: myths and mechanisms

E Heard, RA Martienssen - Cell, 2014 - cell.com
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …

Small RNAs are trafficked from the epididymis to developing mammalian sperm

U Sharma, F Sun, CC Conine, B Reichholf, S Kukreja… - Developmental cell, 2018 - cell.com
The biogenesis of the RNA payload of mature sperm is of great interest, because RNAs
delivered to the zygote at fertilization can affect early development. Here, we tested the …

Transgenerational epigenetic inheritance

A Bošković, OJ Rando - Annual review of genetics, 2018 - annualreviews.org
Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …