Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …

▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain.
Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing …

cAMP (3′, 5′ cyclic adenosine monophosphate) is a second messenger that in eukaryotic
cells induces physiological responses ranging from growth, differentiation, and gene …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact
with antigen-presenting cells. Visualization of these processes has previously been limited …

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from
where they project to practically all brain regions, with ventral areas (hypothalamus, basal …