CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and
Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting …

The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP)
contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the …

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential
component of membrane phosphatides and has been implicated in cognitive functions. Low …

Synapse loss and synaptic dysfunction are pathological processes already involved in the
early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal …

The synthesis of brain phosphatidylcholine may utilize three circulating precursors: choline;
a pyrimidine (eg, uridine, converted via UTP to brain CTP); and a PUFA (eg …

Glioma stem cells (GSCs) promote tumor progression and therapeutic resistance and exhibit
remarkable bioenergetic and metabolic plasticity, a phenomenon that has been linked to …

New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a
presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are …

In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

Although cognitive performance in humans and experimental animals can be improved by
administering omega-3 fatty acid docosahexaenoic acid (DHA), the neurochemical …

This study examined the effects on cognitive behaviors of giving normal adult gerbils three
compounds, normally in the circulation, which interact to increase brain phosphatides …