Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …

Mycobacterium tuberculosis can survive within its host for extended periods of time without
any clinical symptoms of disease and reactivate when the immune system is weakened. A …

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the
various nutrients available during its life cycle. However, in the nutritionally stringent …

Despite the existence of well-characterized, canonical mutations that confer high-level drug
resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance …

Bacterial RNA degradosomes are multienzyme molecular machines that act as hubs for post-
transcriptional regulation of gene expression. The ribonuclease activities of these …

Bacteria adjust gene expression at the post-transcriptional level through an intricate network
of small regulatory RNAs and RNA-binding proteins, including ribonucleases (RNases) …

We have recently found that selected thio-disaccharides possess bactericidal effects against
Mycobacterium tuberculosis but not against Escherichia coli or S taphylococcus aureus …

Ribonucleases (RNases) are responsible for RNA metabolism. RNase J, the core enzyme of
the RNA degradosome, plays an essential role in global mRNA decay. Emerging evidence …

Mycobacterium tuberculosis possesses a significant arsenal of strategies to combat immune
defense of the host organism. Small noncoding RNAs, which constitute the largest group of …

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving
selectively directing disease-causing proteins for degradation through proteolytic systems …