Enhanced permeability and retention (EPR) effect is the physiology-based principal
mechanism of tumor accumulation of large molecules and small particles. This specific issue …

Human serum albumin (HSA) is an abundant plasma protein, which attracts great interest in
the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their …

Thermoresponsive copolymers have attracted considerable interest in both the polymer and
biomaterial literature. They show interesting fundamental behaviour (thermally triggered …

PEGylation is the most common and successful surface-chemistry strategy for reducing
nonspecific accumulation and prolonging blood circulation of inorganic nanoparticles (NPs) …

RNAi technology has brought a new category of treatments for various diseases including
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …

Fullerene (C60), a third carbon allotrope, is a classical engineered material with the
potential application in biomedicine. One of the biologically most relevant features of C60 is …

Inclusion of a tumor-targeting molecule in nanosized delivery systems increases their in vivo
efficacy. However, the biodistribution and pharmacokinetics of the uptake of such particles …

With the discovery of cisplatin, a vast area of applications of metallodrugs in cancer
treatment was opened but due to the side effects caused by the cisplatin complexes …

Following the identification of [Ru (η6-p-cymene) Cl2 (1 H, 1 H, 2 H, 2 H-perfluorodecyl-3-
(pyridin-3-yl) propanoate)], a ruthenium (II)–arene complex with a perfluoroalkyl-modified …

Drug carriers tailored to fit the physicochemical properties of anticancer agents and the
therapeutic peculiarities of tumor management are envisioned for improving the …