Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …

A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated
protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions …

Gain-of-function (GOF) pathogenic variants in the potassium channels KCNQ2 and KCNQ3
lead to hyperexcitability disorders such as epilepsy and autism spectrum disorders …

A high percentage of patients with brain metastases frequently develop neurocognitive
symptoms; however, understanding how brain metastasis co-opts the function of neuronal …

As a significant type of traumatic brain injury (TBI), blast-induced traumatic brain injury (bTBI)
frequently results in severe neurological and psychological impairments. Due to its unique …

Ferroptosis is an iron-dependent cell death mechanism involving the accumulation of lipid
peroxides. As a critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated …

Epilepsy is a neurological disorder caused by the pathological hyper-synchronization of
neuronal discharges. The fundamental research of epilepsy mechanisms and the targets of …

Neurodegenerative disorders are characterized by phenotypic changes and hallmark
proteopathies. Quantifying these in archival human brain tissues remains indispensable for …

Transient brain insults including status epilepticus (SE) can initiate a process termed
'epileptogenesis' that results in chronic temporal lobe epilepsy. As a consequence, the entire …