Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury

AG Yates, T Jogia, ER Gillespie, Y Couch… - Journal of …, 2021 - Springer
Background The acute phase response (APR) to CNS insults contributes to the overall
magnitude and nature of the systemic inflammatory response. Aspects of this response are …

Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury

J Amo-Aparicio, J Garcia-Garcia… - Experimental …, 2022 - Elsevier
Spinal cord injury (SCI) leads to irreversible functional deficits due to the disruption of axons
and the death of neurons and glial cells. The inflammatory response that occurs in the …

Effects of anakinra on the small intestine mucositis induced by methotrexate in rats

F Ozcicek, AV Kara, EM Akbas, N Kurt… - Experimental …, 2020 - jstage.jst.go.jp
Intestinal mucositis is an important problem in the patients receiving cancer treatment. We
aimed to investigate the effect of anakinra, which is a well known anti-oxidant and anti …

Effect of Kineret® on ovarian ischemia reperfusion injury in a rat model

UA Nayki, C Nayki, N Cetin, FK Cimen… - Journal of Obstetrics …, 2016 - Wiley Online Library
Aim To investigate the effect of Kineret® on ischemia reperfusion (IR) injury in rat ovaries.
Methods Rats were divided into four groups: ovarian IR (IRG); 50 mg/kg Kineret®+ ovarian …

Effect of anakinra, an interleukin one beta antagonist, on oxidative testicular damage induced in rats with ischemia reperfusion

E Hirik, B Suleyman, R Mammadov… - Revista internacional de …, 2018 - Elsevier
Background It has been reported in the literature that proinflammatory interleukin-1 beta (IL-
1β) is increased in cases of testicular ischemia reperfusion (I/R) damage. This information …

The role of anakinra in the modulation of intestinal cell apoptosis and inflammatoryresponse during ischemia/reperfusion

M KandemIr, NF Yaşar, M Özkurt… - Turkish Journal of …, 2021 - journals.tubitak.gov.tr
Background/aim: Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain
inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic …

The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats

A Ersoy, C Tanoglu, GN Yazici, TA Coban… - Brazilian Journal of …, 2022 - SciELO Brasil
Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor
antagonist used in rheumatoid arthritis treatment. This study investigated the effect of …

[PDF][PDF] The effect of anakinra to nephrotoxicity with cisplatin induced in rats: Biochemical, gene expression and histopathological evaluation

A Özçiçek, F Özçiçek, F Cimen… - Advances in Clinical …, 2018 - avesis.ebyu.edu.tr
The effect of anakinra to nephrotoxicity with cisplatin induced in rats: Biochemical, gene
expression and histopathological eval Page 1 DOI 10.17219/acem/75775 Copyright © 2018 by …