Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance …

Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

The application of single-cell genome sequencing to large cell populations has been
hindered by technical challenges in isolating single cells during genome preparation. Here …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Accurate measurement of clonal genotypes, mutational processes, and replication states
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …

Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …