MiT/TFE family of transcription factors: an evolutionary perspective
M La Spina, PS Contreras, A Rissone… - Frontiers in Cell and …, 2021 - frontiersin.org
Response and adaptation to stress are critical for the survival of all living organisms. The
regulation of the transcriptional machinery is an important aspect of these complex …
regulation of the transcriptional machinery is an important aspect of these complex …
Autophagy and the lysosomal system in cancer
S Kumar, M Sánchez-Álvarez, FN Lolo, F Trionfetti… - Cells, 2021 - mdpi.com
Autophagy and the lysosomal system, together referred to as the autophagolysosomal
system, is a cellular quality control network which maintains cellular health and homeostasis …
system, is a cellular quality control network which maintains cellular health and homeostasis …
Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
Tuberculosis is a chronic disease that displays several features commonly associated with
biofilm-associated infections: immune system evasion, antibiotic treatment failures, and …
biofilm-associated infections: immune system evasion, antibiotic treatment failures, and …
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia
Y Liu, X Xue, H Zhang, X Che, J Luo, P Wang, J Xu… - Autophagy, 2019 - Taylor & Francis
Mounting attention has been focused on defects in macroautophagy/autophagy and the
autophagy-lysosomal pathway (ALP) in cerebral ischemia. TFEB (transcription factor EB) …
autophagy-lysosomal pathway (ALP) in cerebral ischemia. TFEB (transcription factor EB) …
TFEB safeguards trophoblast syncytialization in humans and mice
W Zheng, Y Zhang, P Xu, Z Wang, X Shao… - Proceedings of the …, 2024 - pnas.org
Nutrient sensing and adaptation in the placenta are essential for pregnancy viability and
proper fetal growth. Our recent study demonstrated that the placenta adapts to nutrient …
proper fetal growth. Our recent study demonstrated that the placenta adapts to nutrient …
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy
ABSTRACT The deacetylase SIRT1 (sirtuin 1) has emerged as a major regulator of
nucleocytoplasmic distribution of macroautophagy/autophagy marker MAP1LC3/LC3 …
nucleocytoplasmic distribution of macroautophagy/autophagy marker MAP1LC3/LC3 …
The role of interferon-gamma and interferon-gamma receptor in tuberculosis and nontuberculous mycobacterial infections
Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) remain the
leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its …
leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its …
Key roles of MiT transcription factors in innate immunity and inflammation
JE Irazoqui - Trends in immunology, 2020 - cell.com
Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB)
and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and …
and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and …
Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) infection induces pulmonary expression of the heme-
degrading enzyme heme oxygenase-1 (HO-1). We have previously shown that …
degrading enzyme heme oxygenase-1 (HO-1). We have previously shown that …
Modulation of inflammation and immune responses by heme oxygenase-1: implications for infection with intracellular pathogens
Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing
equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in …
equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in …