The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
Alcohol and the brain: from genes to circuits
G Egervari, CA Siciliano, EL Whiteley, D Ron - Trends in neurosciences, 2021 - cell.com
Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …
influences intracellular signaling mechanisms, leading to changes in gene expression …
Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility
Exposure to addictive substances impairs flexible decision making. Cognitive flexibility is
mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking …
mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking …
NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits
Z Li, OE Vidjro, G Guo, Y Du, Y Zhou, Q Xie, J Li… - Journal of …, 2022 - Springer
Background Alcohol use disorders result from repeated binge and chronic alcohol
consumption followed by negative effects, such as anxiety, upon cessation. This process is …
consumption followed by negative effects, such as anxiety, upon cessation. This process is …
Whole-brain mapping of direct inputs to dopamine D1 and D2 receptor-expressing medium spiny neurons in the posterior dorsomedial striatum
The posterior dorsomedial striatum (pDMS) is mainly composed of medium spiny neurons
(MSNs) expressing either dopamine D1 receptors (D1Rs) or D2Rs. Activation of these two …
(MSNs) expressing either dopamine D1 receptors (D1Rs) or D2Rs. Activation of these two …
Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons
Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms.
The reinforcement of substance use is mediated by the striatal direct-pathway medium spiny …
The reinforcement of substance use is mediated by the striatal direct-pathway medium spiny …
Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence
High relapse rate during abstinence is a defining characteristic of drug addiction. We
previously found that opioid seeking progressively increases after voluntary abstinence …
previously found that opioid seeking progressively increases after voluntary abstinence …
Preexisting risk-avoidance and enhanced alcohol relief are driven by imbalance of the striatal dopamine receptors in mice
ME Bocarsly, MJ Shaw, E Ventriglia… - Nature …, 2024 - nature.com
Alcohol use disorder (AUD) is frequently comorbid with anxiety disorders, yet whether
alcohol abuse precedes or follows the expression of anxiety remains unclear. Rodents offer …
alcohol abuse precedes or follows the expression of anxiety remains unclear. Rodents offer …
Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum
The dorsal striatum is a brain region involved in action control, with dorsomedial striatum
(DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual …
(DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual …
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior
SC Piantadosi, EE Manning, BL Chamberlain… - Nature …, 2024 - nature.com
Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD).
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …
Striatal hyperactivity has been linked to compulsive behavior generation in correlative …