Living systems use proximity to regulate biochemical processes. Inspired by this
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …

Myriad biological communication events achieve the requisite level of specificity by
exploiting the rich structural and functional diversity of glycoconjugates. Although a wide …

This report highlights the advantages of low-affinity, multivalent interactions to recognize one
cell type over another. Our goal was to devise a strategy to mediate selective killing of tumor …

Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate
carboxypeptidase overexpressed in many forms of prostate cancer. Our laboratory has …

Glycopolymers are receiving increasing interest due to their application in areas, such as
glycomics, medicine, biotechnology, sensors, and separation science. Consequently, new …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Synthetic immunology, the development of synthetic systems capable of modulating and/or
manipulating immunological functions, represents an emerging field of research with …

Glycoconjugates and their applications as lectin ligands in biology have been thoroughly
investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent …

This review addresses the design and synthesis of synthetic glycopolymers. Glycopolymers
with pendant saccharides exhibit high affinities for proteins owing to their multivalency …

We define multivalency to be the operation of multiple molecular recognition events of the
same kind occurring simultaneously between two entities (molecules, molecular aggregates …