Differential analysis of chromatin accessibility and histone modifications for predicting mouse developmental enhancers

S Fu, Q Wang, JE Moore, MJ Purcaro… - Nucleic acids …, 2018 - academic.oup.com
Enhancers are distal cis-regulatory elements that modulate gene expression. They are
depleted of nucleosomes and enriched in specific histone modifications; thus, calling DNase …

A model-based approach to identify binding sites in CLIP-Seq data

T Wang, B Chen, MS Kim, Y Xie, G Xiao - PloS one, 2014 - journals.plos.org
Cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-Seq)
has made it possible to identify the targeting sites of RNA-binding proteins in various cell …

Application of quantitative trait locus mapping and transcriptomics to studies of the senescence-accelerated phenotype in rats

EE Korbolina, NI Ershov, LO Bryzgalov, NG Kolosova - BMC genomics, 2014 - Springer
Background Etiology of complex disorders, such as cataract and neurodegenerative
diseases including age-related macular degeneration (AMD), remains poorly understood …

[PDF][PDF] Peak calling algorithms and their applications for next-generation sequencing technologies

HA Taleb, A AL-Dherasi, S Al-Mosaib, M Alnoud… - Indian J. Nat …, 2019 - researchgate.net
Next-generation sequencing (NGS) technologies have grown significantly since their
introduction, and the focus has been on developing sophisticated analytical tools to handle …

[HTML][HTML] A personal journey on cracking the genomic codes

MQ Zhang - Quantitative Biology, 2021 - journal.hep.com.cn
A personal journey on cracking the genomic codes A personal journey on cracking the genomic
codes Michael Q. Zhang PDF(620 KB) Home Journals Subscription Submission Metrics Top …

FROM A MATHEMATICAL PHYSICIST TO A COMPUTATIONAL BIOLOGIST

MQ Zhang - 2021 - journal.hep.com.cn
In 1977, I entered USTC (University of Science and Technology of China) as Mechanical
Engineering student among the first generation of college admission after the “Cultural …

Understanding RNA Regulation Through Analysis of CLIP-Seq Data

T Wang - 2015 - utswmed-ir.tdl.org
The past decades have witnessed a surge of discoveries revealing RNA regulation as a
central player in cellular processes. The advent of cross-linking immunoprecipitation …