Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

Astrocytes outnumber neurons in the human brain, and they play a key role in numerous
functions within the central nervous system (CNS), including glutamate, ion (ie, Ca2+, K+) …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …

Background and Objective: Stroke is a leading cause of morbidity and mortality in both
developed and developing countries all over the world. The only drug for ischemic stroke …

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …

Ischemic stroke is one of the leading causes of death and long-term disability worldwide;
however, effective clinical approaches are still limited. The transcriptional factor Nrf2 is a …

Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …

Disruption of the blood–brain barrier (BBB) and cerebral edema are the major pathogenic
mechanisms leading to neurological dysfunction and death after ischemic stroke. The brain …

Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …