Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Simple Summary The local anesthetic lidocaine suppresses some cancer cell lines but the
mechanism is unclear. Melastatin-like transient receptor potential 7 (TRPM7) ion channels …

It is well known that tumours arising in different organs are innervated and that 'perineural
invasion'(cancer cells escaping from the tumour by following the nerve trunk) is a negative …

Although surgical resection provides a straightforward and effective treatment for most
malignant solid tumors, tumor recurrence and acute postoperative pain continue to be two …

As the most prevalent cancer for females, breast cancer is also the second most popular
cancer type overall. More efforts are needed to research new drugs and combination …

The use of local anesthetics during surgical treatment of cancer patients is an important part
of perioperative analgesia. In recent years, it has been showed that local anesthetics can …

Anesthetics are extensively used during cancer surgeries. The progression of cancer can be
influenced by perioperative events such as exposure to general or local anesthesia …

Background A large number of preclinical studies have shown that local anesthetics have a
direct inhibitory effect on tumor biological activities, including cell survival, proliferation …

The tumor microenvironment (TME) is complex and involves many different cell types that
seemingly work together in helping cancer cells evade immune monitoring and survive …