Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …

Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …

Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
developing sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …

Microglia play a role in the emergence and preservation of a healthy brain
microenvironment. Dysfunction of microglia has been associated with neurodevelopmental …

Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq),
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …