The tRNA identity landscape for aminoacylation and beyond
R Giegé, G Eriani - Nucleic Acids Research, 2023 - academic.oup.com
Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …
Expanding the genetic code
Recently, a general method was developed that makes it possible to genetically encode
unnatural amino acids with diverse physical, chemical, or biological properties in …
unnatural amino acids with diverse physical, chemical, or biological properties in …
A chemical toolkit for proteins—an expanded genetic code
J Xie, PG Schultz - Nature Reviews Molecular Cell Biology, 2006 - nature.com
Recently, a method to encode unnatural amino acids with diverse physicochemical and
biological properties genetically in bacteria, yeast and mammalian cells was developed …
biological properties genetically in bacteria, yeast and mammalian cells was developed …
A general approach for the generation of orthogonal tRNAs
L Wang, PG Schultz - Chemistry & biology, 2001 - cell.com
Background: The addition of new amino acids to the genetic code of Escherichia coli
requires an orthogonal suppressor tRNA that is uniquely acylated with a desired unnatural …
requires an orthogonal suppressor tRNA that is uniquely acylated with a desired unnatural …
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
T Kobayashi, O Nureki, R Ishitani… - Nature Structural & …, 2003 - nature.com
The archaeal/eukaryotic tyrosyl-tRNA synthetase (TyrRS)–tRNATyr pairs do not cross-react
with their bacterial counterparts. This' orthogonal'condition is essential for using the archaeal …
with their bacterial counterparts. This' orthogonal'condition is essential for using the archaeal …
Site-specific incorporation of unnatural amino acids into Escherichia coli recombinant protein: methodology development and recent achievement
S Smolskaya, YA Andreev - Biomolecules, 2019 - mdpi.com
More than two decades ago a general method to genetically encode noncanonical or
unnatural amino acids (NAAs) with diverse physical, chemical, or biological properties in …
unnatural amino acids (NAAs) with diverse physical, chemical, or biological properties in …
An expanding genetic code
J Xie, PG Schultz - Methods, 2005 - Elsevier
A general method was recently developed that makes it possible to genetically encode
unnatural amino acids (UAAs) with diverse physical, chemical or biological properties in …
unnatural amino acids (UAAs) with diverse physical, chemical or biological properties in …
[HTML][HTML] Class I tyrosyl‐tRNA synthetase has a class II mode of cognate tRNA recognition
Bacterial tyrosyl‐tRNA synthetases (TyrRS) possess a flexibly linked C‐terminal domain of∼
80 residues, which has hitherto been disordered in crystal structures of the enzyme. We …
80 residues, which has hitherto been disordered in crystal structures of the enzyme. We …
Pathways to disease from natural variations in human cytoplasmic tRNAs
Perfectly accurate translation of mRNA into protein is not a prerequisite for life. Resulting
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
2008-11-17 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …