[HTML][HTML] The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery

M Romanazzi, ETM Filardi, GMM Pires, MF Cerveja… - Biomolecules, 2025 - mdpi.com
Serine proteases are multifunctional and versatile venom components found in viper
snakes, including the Bothrops species, a widely distributed genus notorious for causing the …

Antivenom: An immunotherapy for the treatment of snakebite envenoming in sub-Saharan Africa

MM Mender, F Bolton, C Berry, M Young - Advances in protein chemistry …, 2022 - Elsevier
Snakebite envenoming (SBE) leads to significant morbidity and mortality, resulting in over
90,000 deaths and approximately 400,000 amputations annually. In sub-Saharan Africa …

Crotoxin B: heterologous expression, protein folding, immunogenic properties, and irregular presence in crotalid venoms

MA Mejía-Sánchez, H Clement, LL Corrales-García… - Toxins, 2022 - mdpi.com
Crotoxin complex CA/CB and crotamine are the main toxins associated with Crotalus
envenomation besides the enzymatic activities of phospholipases (PLA2) and proteases …

cDNA Cloning, Heterologous Expression, Cytotoxicity, and Inhibitory Effects of a Disintegrin from Bothrops ammodytoides Venom

H Clement, LL Corrales-García… - International Journal of …, 2023 - Springer
An mRNA transcript that codes for a Disintegrin and a Metalloprotease from a venom gland
of the viper Bothrops ammodytoides was isolated. Vector pCR® 2.1-TOPO was used to …

Heterologous Expression and Immunogenic Potential of the Most Abundant Phospholipase A2 from Coral Snake Micrurus dumerilii to Develop Antivenoms

LE Romero-Giraldo, S Pulido, MA Berrío, MF Flórez… - Toxins, 2022 - mdpi.com
Micrurus dumerilii is a coral snake of clinic interest in Colombia. Its venom is mainly
composed of phospholipases A2 being MdumPLA2 the most abundant protein …

Antimicrobial, toxicological, and antigenic characteristics of three scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff …

LL Mendoza-Tobar, H Clement, I Arenas… - Acta tropica, 2024 - Elsevier
The venom fractions of three buthid scorpion species from Colombia, C. margaritatus, T.
pachyurus and T. n. sp. aff. metuendus, were examined for antimicrobial and toxicity toward …

[HTML][HTML] Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom

MH Salazar, H Clement, LL Corrales-García… - Toxicon: X, 2022 - Elsevier
Background The development of more effective antivenoms remains a necessity for
countries where scorpionism is a public health problem. Also, the regionalization of …

Caracterización bioquímica, funcional y biológica del veneno de Crotalus durissus cumanensis colombiana

AL Rodríguez-Vargas - 2023 - dialnet.unirioja.es
En el veneno de serpientes cascabel predomina la actividad neurotóxica de las fosfolipasas
tipo A2 (PLA2) y las miotoxinas de bajo peso molecular, además de los efectos …