Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Molecular pathways of nonalcoholic fatty liver disease development and progression

F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease

E Makri, A Goulas, SA Polyzos - Archives of medical research, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an
estimated rising prevalence, in concert with the epidemics of obesity and type 2 diabetes …

Pegbelfermin (BMS‐986036), PEGylated FGF21, in patients with obesity and type 2 diabetes: results from a randomized phase 2 study

ED Charles, BA Neuschwander‐Tetri, J Pablo Frias… - …, 2019 - Wiley Online Library
Objective Obesity and type 2 diabetes mellitus (T2DM) are risk factors for nonalcoholic fatty
liver disease, including nonalcoholic steatohepatitis. This study assessed pegbelfermin …

Pathophysiological, molecular and therapeutic issues of nonalcoholic fatty liver disease: an overview

S Marchisello, A Di Pino, R Scicali, F Urbano… - International journal of …, 2019 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease

V Azzu, M Vacca, S Virtue, M Allison, A Vidal-Puig - Gastroenterology, 2020 - Elsevier
Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …

[HTML][HTML] The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of …

SC Shabalala, PV Dludla, L Mabasa, AP Kappo… - Biomedicine & …, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

[HTML][HTML] Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic …

A Borrelli, P Bonelli, FM Tuccillo, ID Goldfine, JL Evans… - Redox biology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in industrialized countries. NAFLD progresses through the inflammatory phase of non …

AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions

A Lonardo, F Nascimbeni, G Targher… - Digestive and Liver …, 2017 - Elsevier
This review summarizes our current understanding of nonalcoholic fatty liver disease
(NAFLD), a multi-factorial systemic disease resulting from a complex interaction between a …

Adipokines in nonalcoholic fatty liver disease

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2016 - Elsevier
Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …