Attrition due to nonclinical safety represents a major issue for the productivity of
pharmaceutical research and development (R&D) organizations, especially during the …

With the need to understand the potential biological impact of the plethora of nanoparticles
(NPs) being manufactured for a wide range of potential human applications, due to their …

Micronucleus (MN) is the small nucleus that forms whenever a chromosome or its fragment
is not incorporated into one of the daughter nuclei during cell division. Any form of genotoxic …

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite
chemical evaluation for human health risk assessment. In this study, we combined the high …

Abstract The International Life Sciences Institute (ILSI) Health and Environmental Sciences
Institute (HESI) Project Committee on the Relevance and Follow‐up of Positive Results in In …

Mycotoxins are produced by a number of fungal genera spp., for example, Aspergillus,
Penicillium, Alternaria, Fusarium, and Claviceps. Beauvericin (BEA) and Ochratoxin A (OTA) …

This review focuses on the use of in vitro bioassays for the hazard assessment of food
contact materials (FCM) as a relevant strategy, in complement to analytical methods. FCM …

The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to
several automated scoring approaches. Flow cytometry is one such scoring platform that has …

The increased use of engineered nanomaterials (ENM) such as SiO2 and TiO2 in industrial
products, especially in food, raises concerns with regard to their effect on human health. In …

As part of a larger effort to provide proof-of-concept in vitro-only risk assessments, we have
developed a suite of high-throughput assays for key readouts in the p53 DNA damage …